Understanding the Retadose Report
This page helps healthcare providers interpret the patient export from Retadose, a pharmacokinetic-based tracking tool for retatrutide. Retadose is not a medical device. It is a self-monitoring aid that uses published PK parameters to estimate drug concentration and guide dosing conversations.
What is Retadose?
Retadose is a free dosing tracker for people using retatrutide. Users log each injection dose, complete daily wellbeing check-ins, and receive PK-modelled concentration estimates. The tool assists with the GLP-1 washout challenge — managing side effects and dose-response plateaus that are common with triple-agonist peptides. It is not a medical device and does not provide clinical advice.
For more information about retatrutide side effects and the stacking mechanism, see our side effects overview.
Reading the Patient Export
When a patient shares their Retadose export (via the "Export for Provider" button), you will see the following sections:
Patient Information
Target Level is the user's current PK target in estimated ng/mL. The system adjusts this automatically based on check-in data — lowering it when side effects are detected and raising it when tolerance improves. The GI Sensitive flag indicates the user has been marked (automatically or manually) as GI-sensitive, which uses a lower wellbeing threshold before the system reduces the target.
Dose History
A chronological list of self-reported injection doses with dates and injection sites. Accuracy depends on the patient's logging compliance.
Composite Wellbeing Score
The composite score is a self-reported wellbeing index on a 0–100 scale, derived from five equally weighted domains:
| Domain | What it measures | Scale |
|---|---|---|
| Appetite | Ability to eat adequate meals | 1–10 |
| Energy | Subjective energy and fatigue | 1–10 |
| GI comfort | Gastrointestinal symptoms (nausea, bloating) | 1–10 |
| Focus | Cognitive clarity and concentration | 1–10 |
| Mood | Overall emotional wellbeing | 1–10 |
The composite is the simple mean of all five domains, rescaled to 0–100. Higher is better.
| Score range | Colour | Interpretation |
|---|---|---|
| 70–100 | Green | Good — tolerating well |
| 40–69 | Yellow | Moderate — some side effects present |
| 0–39 | Red | Poor — significant side effects |
This is not a validated clinical instrument. It is a self-reported tracking tool intended to surface trends over time.
Alert Flags
Retadose generates alert flags when patterns are detected in check-in data — for example, sustained low wellbeing while the estimated drug concentration is within the active range. Alerts are informational and do not constitute diagnoses.
Weight Trend
Self-reported weight entries. The trend line uses a simple regression. These values are not clinically verified.
Limitations
- All data is self-reported by the patient.
- PK estimates use a population-average model (Coskun et al. 2022) with optional personal calibration. Individual variation is expected.
- The composite score is not a validated patient-reported outcome measure (PROM). It is a monitoring aid.
- Retadose is not FDA-cleared, CE-marked, or otherwise approved as a medical device.
- The tool does not replace clinical assessment, blood work, or therapeutic drug monitoring.